Recently, great progress has been made in pdlsc transplantation. Progenitor and stem cells are of particular interest in periodontal wound healing and regeneration as they are most likely the parental cells of synthetic cells e. Periodontal regeneration by allogeneic transplantation of adipose. Stem cells, tissue engineering and periodontal regeneration. Abstractperiodontal regeneration is considered to be biologically possible but. The field of regenerative medicine is discovering how to use stem cells to stimulate the body to generate new tissue to replace areas affected and damaged by disease. Promising treatment for periodontitis gum regeneration. Since then, other stem cells have been found to possess the ability to form multiple periodontal tissues. This kind of treatment paradigm is important because commercially available stem cells that represent a cell based therapy specifically developed to treat periodontal tissue regeneration will.
Numerous types of stem cells have been isolated from dental tissue, such as dental pulp stem cells dpscs, stem cells isolated from human pulp of exfoliated deciduous teeth shed, periodontal ligament stem cells pdlscs, stem cells from apical papilla scaps, and dental follicle cells dfcs. Dental stem cell and dental tissue regeneration springerlink. Application of stem cells in the oral and maxillofacial. Despite unmet clinical needs for reconstruction of tissues lost in congenital anomalies, infections, trauma, or tumor resection, how orofacial stem progenitor cells contribute to tissue development, pathogenesis, and regeneration. These structures are the target of most common dental diseasesdental caries and periodontal diseases. Osteoblasticcementoblastic and neural differentiation of. In recent years, mesenchymal stem cells mscs have emerged as a promising therapy for periodontal regeneration in animal studies 4, 5 and in human studies 6. The scope of stem cells in periodontal regeneration. We consider and describe the main stem cell populations that have been utilized with regard to periodontal regeneration, including bone marrowderived. Stem cells in gum regeneration and lanap preserve your. Stem cells in periodontal regeneration semantic scholar.
The identification of stem cells from human pdl tissues, termed pdl stem cells pdlscs, in 2004, led to a new era of research on periodontal regeneration 14. During tooth development, the periodontal stem cells. Periodontal ligament stem cells pdlscs, which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Curr oral health rep induced pluripotent stem cells and periodontal regeneration mi du 0 1 xuejing duan 0 1 pishan yang 0 1 0 department of stomatology, shandong provincial hospital affiliated to shandong university, no. Pdlscs are a kind of somatic stem cells that show potential to differentiate into multiple cell. Periodontal regeneration by allogeneic transplantation of. Mesenchymal stem cell exosomes enhance periodontal.
Gene therapy, stem cells, and rna interference periodontal disease is a major public health issue and the development of effective therapies to treat the disease and regenerate periodontal. Regeneration of periodontal tissues using ex vivo expanded cells has been introduced and studied, although appropriate methodology has not yet been established. They can differentiate into endothelial, perivascular, neural, bone or muscle cells. The regeneration of lostdamaged support tissue in the periodontium, including. This article is from balkan journal of medical genetics. These stem cells have drawn considerable attention since they are very similar to embryonic stem cells, hence considerable potential in periodontal regeneration 85. Utilizing human gmscs as a promising source for periodontal tissue regeneration. The use of stem cells for periodontal regeneration is a hot field in. Terminology glossary of periodontal terms a graft is any tissue. The goal of periodontal treatment is to control the infections and reconstruct the structure and function of periodontal tissues including cementum, periodontal ligament pdl fibers, and bone. Enhancement of periodontal tissue regeneration by transplant of bone marrow mesenchymal stem cells. Periodontal regeneration an overview sciencedirect topics. This setting creates a healing coagulum containing the stem cells from patients own bone marrow.
Periodontal regeneration in swine after cell injection and. Stem cells used so far in periodontal regeneration have been identified, and their characteristics that aid in periodontal regeneration, and various methods used to incorporate them examined in detail. Their most common source is the bone marrow hematopoietic stem cells or bone marrow stromal cells mesenchymal stromal stem cells. Stem cells and periodontal regeneration wiley online library. The pdl is a fibrous connective tissue that contains specialized cells. Periodontal disease is characterized by the destruction of tooth supporting tissues. Request pdf stem cells and periodontal regeneration periodontitis is an inflammatory disease which manifests clinically as loss of supporting periodontal tissues including periodontal ligament. It also covers various experimental strategies that could be used to direct lineagespeci. The discovery of periodontal ligament stem cells pdlscs highlighted the possibility for development of tissue engineering technologybased therapeutics for disrupted periodontium. Colgate australian clinical dental research centre, the university of adelaide, south. To develop a novel regenerative and adhesive hydrogel encapsulating patients gingival stem cell which can potentially be used as an adhesive dental hydrogel for periodontal tissue regeneration. The use of mesenchymal stem cell msc therapy offers the potential to develop a completely novel and improved method of periodontal regeneration compared to existing methods. Other stem cells, such as bone marrow stromal stem cells and adipose tissue stem cells. Scaffold technology and biomaterials for stem cell based tissue regeneration in the oral and maxillofacial region.
We developed a novel cell transplant method for periodontal regeneration using periodontal ligament stem cell. Pdf stem cells, tissue engineering and periodontal. Postnatal orofacial tissues harbor rare cells that exhibit stem cell properties. Mesenchymal stem cells and periodontal regeneration. Guided tissue regeneration one of the crucial cellular events is recruitment of cells as the cell type selection determines whether healing occurs by repair or regeneration. Characterization and culture of stem cells derived from the oral and maxillofacial region e. Among the various stem cell types used for cytotherapy and tissue engineering, mscs are currently proposed as an attractive cell source for bone and tooth regeneration due to their potential. The ultimate goal of periodontal therapy is the regeneration of these lost structures.
Chronic periodontitis is an inflammatory disease, resulting in. Periodontal ligament stem cells pdlscs possess the capacity of selfrenewal and multilineage differentiation and are likely to recover lost alveolar bone. School of dentistry, the university of adelaide, south australia. Stem cells and periodontal regeneration request pdf. One of the critical requirements for a tissue engineering approach is the delivery of ex vivo expanded progenitor populations or the mobilization of endogenous. The destruction and loss of periodontal fixation is a worldwide medical concern and is one of the leading causes of tooth loss, representing a critical challenge for the clinical regenerative. Gingival mesenchymal stem cells as a novel treatment. Review article critical issues in periodontal regeneration. A novel approach for periodontal tissue regeneration is to employ different populations of dental stem cells in order to recapitulate key events during periodontal tissue development. These last can be potential candidates for periodontal regeneration 15.
When considering application to periodontal regeneration, stem cells derived from the tissues surrounding the teeth, i. Periodontal regeneration with human stem cells decisions. Periodontal regeneration using periodontal ligament stem. Chronic periodontitis is a disease of the periodontium characterized by irreversible damage in connective tissue attachment and supporting alveolar bone. Stem cells from the periodontal ligament pdlscs are promising for periodontal regeneration because they can undergo guided differentiation under specialized conditions.
In the last step, the uses a specific setting on the laser. At the cellular level, pr is a complex process that requires coordination between the proliferation, differentiation and development of various cell types. The dental complex is a multistructure organ composed of highly mineralized tissues i. Advances in stem cell biology and regenerative medicine have presented opportunities for tissue engineering and genebased approaches in. Mesenchymal stem cells, periodontal ligament stem cells, periodontal regeneration.
Stem cells are the latest entrant in periodontal regeneration. The identification and manipulation of stem cells has greatly advanced regenerative medicine and has contributed to development of tissue engineeringbased clinical therapies 19. Mesenchymal stem cells for periodontal tissue regeneration. Induced pluripotent stem cells and periodontal regeneration. Periodontitis is a prevalent infectious disease worldwide, causing the damage of periodontal support tissues, which can eventually lead to tooth loss.
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